Molecular Regulation of Histamine Synthesis

Molecular Regulation of Histamine Synthesis

Blog Article

Histamine is a critical mediator of IgE/mast cell-mediated here anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion.Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes navy drapery fabric carboxyl group from histidine.Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is still poorly understood.In this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis.